Invitrogen™ Phospho-Caveolin 2 (Ser23) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5118635

Catalog No. PIPA5118635

Description

Antibody detects endogenous levels of Caveolin 2 only when phosphorylated at Ser23.

Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.

Specifications

• Antigen: Phospho-Caveolin 2 (Ser23)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CAV2
• Gene Alias: AI447843; CAV; CAV2; caveolae; caveolae protein, 20-kD; caveolin 2; caveolin 2 isoform a and b; caveolin-2; MGC12294; Phospho-CAV2
• Host Species: Rabbit
• Purification Method: sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12390, 363425, 858
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P51636, Q2IBC5, Q9WVC3
• Gene Symbols: CAV2
• Immunogen: A synthesized peptide derived from human CAV2(Accession P51636), corresponding to amino acid residues around phosphorylated Ser23.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov