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Invitrogen™ Phospho-Cdc25A (Ser76) Polyclonal Antibody
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Catalog No. PIPA5114558
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PIPA5114558 100 μL
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Catalog No. PIPA5114558 Supplier Invitrogen™ Supplier No. PA5114558
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of CDC25A only when phosphorylated at Ser76, which site historically referenced as Ser75.

CDC25a is a member of the CDC25 family of phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B, and CDC25C. These three genes function at different phases of the cell cycle. CDC25a is required for progression through G1 and S phases of the cell cycle. CDC25a activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Cdc25A (Ser76)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene CDC25A
Gene Accession No. P30304, P48964, P48965
Gene Alias CDC25 isoform A1-CAG; CDC25A; CDC25A2; CDC25A2-CAG isoform; Cdc25m3; cell division cycle 25A; D9Ertd393e; dual specificity phosphatase Cdc25A; EC 3.1.3.48; M-phase inducer phosphatase 1; MPIP1
Gene Symbols CDC25A
Host Species Rabbit
Immunogen A synthesized peptide derived from human CDC25A(Accession P30304), corresponding to amino acid residues around phosphorylated Ser76.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12530, 171102, 993
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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