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Invitrogen™ Phospho-CDK4 (Thr172) Polyclonal Antibody
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Catalog No. PIPA564482
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PIPA564482 100 μL
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Catalog No. PIPA564482 Supplier Invitrogen™ Supplier No. PA564482
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Description

Rabbit Polyclonal Antibody

Phospho-CDK4 (Thr172) Polyclonal Antibody detects endogenous levels of CDK4 only when phosphorylated at Thr172.

CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-CDK4 (Thr172)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide; pH 7.4
Gene Cdk4
Gene Accession No. P11802, P30285, P35426
Gene Alias Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; p34>PSK-J3>/cdk4; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903)
Gene Symbols Cdk4
Host Species Rabbit
Immunogen A synthesized peptide derived from human CDK4 (Phospho-Thr172).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1019, 12567, 94201
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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