Invitrogen™ Phospho-CDK6 (Thr177) Recombinant Superclonal™ Antibody (16HCLC)

Catalog No.	Quantity
PI711588	100 μg

Catalog No. PI711588 Supplier Invitrogen™ Supplier No. 711588

Description

Rabbit Recombinant Superclonal Antibody

This antibody is predicted to react with Monkey, Pig, Horse and Bovine Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called 'Recombinant polyclonal antibody', this product is now rebranded as 'Recombinant Superclonal™ antibody'. The physical product and the performance remain unchanged.

CDK6 functions as a cell-cycle initiator protein. This protein is coexpressed and copurified with CyclinD1. They are critical regulators of cell cycle progression. The prototype member of this family, p34cdc2, and a related protein cdk2, function late in the cycle while cdk4 and cdk6 are critically involved in G1 to S progression. CDK6 is essential for cell proliferation within the dentate gyrus of the hippocampus and the cuventricular zone of the lateral ventricles. Mutations in the gene results in microcephaly 12, primary, autosomal recessive (MCPH12).

Specifications

• Antigen: Phospho-CDK6 (Thr177)
• Applications: Immunocytochemistry
• Classification: Recombinant Superclonal
• Clone: 16HCLC
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.2-7.4
• Gene: CDK6
• Gene Accession No.: Q00534, Q64261
• Gene Alias: 5830411I20; AI504062; CDK6; CDKN6; Cell division protein kinase 6; CR2 protein kinase; Crk2; cyclin dependent kinase 6; cyclin-dependent kinase 6; MCPH12; MGC59692; PLSTIRE; Serine/threonine-protein kinase PLSTIRE
• Gene Symbols: CDK6
• Host Species: Rabbit
• Immunogen: Peptide corresponding to Human CDK4 (169-175).
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1021, 12571
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG