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Invitrogen™ Phospho-CENTB1 (Ser554) Polyclonal Antibody
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Catalog No. PIPA5105821
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PIPA5105821 100 μL
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Catalog No. PIPA5105821 Supplier Invitrogen™ Supplier No. PA5105821
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of Centaurin beta-1 only when phosphorylated at Ser554.

ACAP1, also known as Centaurin-beta-1 (CENTB1), is a 740 amino acid containing transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain and a PH domain that binds to phospholipids. ACAP1, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6), is required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. It mediates CENTB1-binding to phosphatidylinositol 3,5-bisphosphate (PIP2) or phosphatidylinositol 3,4,5-trisphosphate (PIP3) containing membranes. Along with ACAP2, ACAP1 is recruited to platelet-derived growth factor (PDGF) induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, while over expression inhibited ruffle formation. It is widely expressed in most tissues with high expression in lung and spleen and low expression in heart, kidney, liver and pancreas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-CENTB1 (Ser554)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ACAP1
Gene Accession No. Q15027, Q8K2H4
Gene Alias Acap1; Arf GAP with coiled coil, ANK repeat and PH domains 1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; centaurin beta 1; centaurin, beta 1; centaurin-beta-1; Centb1; cnt-b1; KIAA0050
Gene Symbols ACAP1
Host Species Rabbit
Immunogen A synthesized peptide derived from human ACAP1(Accession Q15027), corresponding to amino acid residues around phosphorylated Ser554.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216859, 9744
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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