Invitrogen™ Phospho-cGAS (Ser420) Polyclonal Antibody

Catalog No.	Quantity
PIPA5121350	100 μL

Catalog No. PIPA5121350 Supplier Invitrogen™ Supplier No. PA5121350

Description

Rabbit Polyclonal Antibody

Positive test controls include: 293T, C6. Immunogen sequence: FCSYH.

cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of 2', 5' phosphodiester linkage at the GpA step and the formation of 3', 5' phosphodiester linkage at the ApG step. This produces c[G(2',5')pA(3'5')p] responses. cGAS also binds cytosolic DNA directly, leading to the activation and synthesis of cGAMP. Then, a second messenger binds to and activates TMEM173/STING thereby triggering type-I interferon production. cGAS is also involved in innate immune sensorship of infection, detection of DNA from bacteria, response to cellular stress, DNA damage, and regulation of cellular senescence.

Specifications

• Antigen: Phospho-cGAS (Ser420)
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.57 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene: CGAS
• Gene Accession No.: Q8N884
• Gene Alias: C6orf150; h-cGAS; MB21D1
• Gene Symbols: CGAS
• Host Species: Rabbit
• Immunogen: Synthetic peptide.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 115004, 682147
• Target Species: Human, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG