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Invitrogen™ Phospho-CHK2 (Thr68) Polyclonal Antibody
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Catalog No. PIPA578361
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100 μL
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PIPA578361 100 μL
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Catalog No. PIPA578361 Supplier Invitrogen™ Supplier No. PA578361
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Description

Rabbit Polyclonal Antibody

Positive Control: HeLa, 293T, 293T (100μM etoposide for 2hr) Predicted Reactivity: Pig (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-CHK2 (Thr68)
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.73 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Chek2
Gene Accession No. O96017
Gene Alias CDS1; cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; Chek2; Chk2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; HuCds 1; HuCds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; Rad53; Rad53 homolog; RP11-436C9.1; Serine/threonine protein kinase Chk2; serine/threonine-protein kinase Chk2
Gene Symbols Chek2
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide surrounding phospho Thr68 of human Chk2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11200
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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