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Phospho-CPI17 alpha (Thr38) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985882
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50-198-5882 100 μL
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Catalog No. 50-198-5882 Supplier Bioss Supplier No. BS4073R
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Rabbit Polyclonal Antibody

CPI-17 is a phosphorylation-dependent inhibitory protein for smooth muscle myosin phosphate. CPI-17 was originally identified as a PKC-potentiated inhibitory protein of protein phosphatase-1, which is dominantly expressed in smooth muscle. Phosphorylation at Threonine 38, in vitro, by PKC or Rho-kinase enhances the inhibitory potency toward myosin phosphatase. CPI-17 is also phosphorylated at Threonine 38 by protein kinase N and might be involved in the calcium sensitization of smooth muscle contraction as a downstream effector of Rho and/or arachidonic acid. CPI-17 is dually phosphorylated at Serine 12 and Threonine 38 by a MYPT-associated kinase, M110 kinase.

Specifications

Antigen Phospho-CPI17 alpha (Thr38)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene PPP1R14A
Gene Accession No. Q96A00
Gene Alias 1110001M11Rik; 17 kDa PKC-potentiated inhibitory protein of PP1; 17-kDa PKC-potentiated inhibitory protein of PP1; 17-KDa protein; Cpi; Cpi17; CPI-17; PKC-potentiated inhibitory protein of PP1; PPP1INL; Ppp1r14a; Protein kinase C-potentiated inhibitor protein of 17 kDa; protein phosphatase 1 regulatory inhibitor subunit 14A; Protein phosphatase 1 regulatory subunit 14A; protein phosphatase 1, regulatory (inhibitor) subunit 14A
Gene Symbols PPP1R14A
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human CPI17 alpha around the phosphorylation site of Thr38.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 94274
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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