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Phospho-CREB (Ser133) Rabbit anti-Human, Mouse, APC, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Invitrogen MA527989

Catalog No. PIMA527989


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Description

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer ft.s Disease, histiocytoma and soft tissue melanoma.
Specifications

Specifications

Phospho-CREB (Ser133)
Recombinant Monoclonal
APC
CREB1
Liquid
Rabbit
IgG1, kappa
100 tests
4° C
Primary
12912, 1385
Flow Cytometry
CREBS133-4D11
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
P16220, Q01147
CREB1
A synthetic phospho-peptide corresponding to residues surrounding Ser133 of human phospho CREB
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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