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  6. Invitrogen™ Phospho-CrkL (Tyr207) Recombinant Rabbit Monoclonal Antibody (CrkLY207-G4), FITC, Invitrogen™

Invitrogen™ Phospho-CrkL (Tyr207) Recombinant Rabbit Monoclonal Antibody (CrkLY207-G4), FITC, Invitrogen™

Catalog No. PIMA537259
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PIMA537259 10 Tests
PIMA536971 100 Tests
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Catalog No. PIMA537259 Supplier Invitrogen™ Supplier No. MA537259
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Description

Rabbit Recombinant Monoclonal Antibody

The CRKL gene encodes the CRK-like protein, an adaptor protein that plays a crucial role in intracellular signaling pathways related to cell proliferation, differentiation, and migration. CRKL contains SH2 and SH3 domains that facilitate interactions with other signaling molecules, influencing multiple pathways such as the MAPK, PI3K, and STAT pathways. It is involved in processes like cytoskeleton reorganization and immune cell signaling, with significant implications for development and cancer. CRKL is notably associated with Philadelphia chromosome-positive leukemias, where it interacts with the BCR-ABL fusion protein, contributing to leukemogenesis. Additionally, dysregulation of CRKL can affect cardiovascular development, leading to congenital heart defects. Research into CRKL focuses on understanding its role in signal transduction and its potential as a therapeutic target due to its involvement in oncogenic and developmental pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-CrkL (Tyr207)
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone CrkLY207-G4
Conjugate FITC
Formulation PBS with 0.20% BSA and 0.09% sodium azide
Gene CRKL
Gene Accession No. P46109, P47941
Gene Alias 1110025F07Rik; AA589403; AI325100; CRK like proto-oncogene, adaptor protein; CRKL; crkl {ECO:0000312; crk-like protein; crk-like protein {ECO:0000250; Crkol; EMBL:AAH85865.1, ECO:0000312; OTTHUMP00000198539; RGD:1308531}; UniProtKB:P46109}; v-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v-crk sarcoma virus CT10 oncogene homolog-like
Gene Symbols CRKL
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Tyr207 of human phospho CrkL.
Purification Method Protein A/G
Quantity 10 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12929, 1399
Target Species Human, Mouse
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG κ
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