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Invitrogen™ Phospho-CtIP (Ser327) Polyclonal Antibody
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Catalog No. PIPA5143626
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100 μL
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PIPA5143626 100 μL
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Catalog No. PIPA5143626 Supplier Invitrogen™ Supplier No. PA5143626
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Description

Rabbit Polyclonal Antibody

Specific for endogenous levels of the ~100 kDa CtIP protein phosphorylated at Ser327. Immunolabeling is completely eliminated by treatment with lambda-phosphatase.

CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-CtIP (Ser327)
Applications Western Blot
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation 10mM HEPES with 100μg/mL BSA, 50% glycerol, 150mM NaCl and no preservative; pH 7.5
Gene Rbbp8
Gene Accession No. Q99708
Gene Alias 9930104E21Rik; COM1; CtBP-interacting protein; CtIP; DNA endonuclease RBBP8; JWDS; RB binding protein 8, endonuclease; RBBP8; RBBP-8; retinoblastoma binding protein 8; retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; RGD1308872; RIM; SAE2; SCKL2; Sporulation in the absence of SPO11 protein 2 homolog
Gene Symbols Rbbp8
Host Species Rabbit
Immunogen Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327 of human CtIP, conjugated to keyhole limpet hemocyanin (KLH).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5932
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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