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Invitrogen™ Phospho-Cullin 4B (Thr48) Polyclonal Antibody
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Catalog No. PIPA5105358
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PIPA5105358 100 μL
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Catalog No. PIPA5105358 Supplier Invitrogen™ Supplier No. PA5105358
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of CUL4B only when phosphorylated at Thr48.

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Cullin 4B (Thr48)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CUL4B
Gene Accession No. A2A432, Q13620
Gene Alias 2700050M05Rik; AA409770; CUL4B; CUL-4B; cullin 4B; cullin-4B; EGK_20888; KIAA0695; mKIAA0695; MRXHF2; MRXS15; MRXSC; RGD1564494; SFM2
Gene Symbols CUL4B
Host Species Rabbit
Immunogen A synthesized peptide derived from human CUL4B(Accession Q13620), corresponding to amino acid residues around phosphorylated Thr48.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 302502, 72584, 8450
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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