Phospho-Cyclin B3 (Ser284) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA572387

Catalog No. PIPA572387

Description

Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes. The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle, thereby regulating kinase activity. Cyclin B3, also known as CCNB3 or CYCB3, is a 1,395 amino acid nuclear protein that belongs to the cyclin family of regulatory proteins. Expressed in testis with lower expression in a variety of other tissues, cyclin B3 is thought to be required for early meiotic prophase I, playing an important role in the meiotic cell cycle. Three isoforms of cyclin B3 exist due to alternative splicing events.

Specifications

• Antigen: Phospho-Cyclin B3 (Ser284)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCNB3
• Gene Alias: CCNB3; CYCB3; cyclin B3; CyclinB3; G2/mitotic-specific cyclin-B3; Protein Ccnb3; RGD1564367
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 317389
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Dot Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: 0
• Gene Symbols: CCNB3
• Immunogen: KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S284 of rat CCNB3
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG