Invitrogen™ Phospho-Cyclin C (Ser275) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599476

Catalog No. PIPA599476

Description

Antibody detects endogenous levels of Cyclin C only when phosphorylated at Ser275.

Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk 8, a novel protein kinase of the cdk family. It is suggested that cyclin C and cdk 8 control RNA polymerase II function. Human cdk 8 cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth regulatory signals.

Specifications

• Antigen: Phospho-Cyclin C (Ser275)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCNC
• Gene Alias: AI451004; AU020987; CCNC; CG1C; CycC; cyclin C; cyclin-C; dJ199J3.4 (cyclin C); hSRB11; SRB11 homolog
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114839, 51813, 892
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P24863, P39947, Q62447
• Gene Symbols: CCNC
• Immunogen: A synthesized peptide derived from human CCNC(Accession P24863), corresponding to amino acid residues around phosphorylated Ser275.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov