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Invitrogen™ Phospho-Cyclin C (Ser275) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537510

Catalog No. PIPA537510


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Description

Description

A suggested positive control for Western blot is NIH-3T3 or A549 cells; suggested positive control for IHC is human breast carcinoma.

Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk 8, a novel protein kinase of the cdk family. It is suggested that cyclin C and cdk 8 control RNA polymerase II function. Human cdk 8 cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth regulatory signals.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-Cyclin C (Ser275)
Polyclonal
Unconjugated
CCNC
AI451004; AU020987; CCNC; CG1C; CycC; cyclin C; cyclin-C; dJ199J3.4 (cyclin C); hSRB11; SRB11 homolog
Rabbit
Affinity Chromatography
RUO
114839, 51813, 892
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P24863, P39947, Q62447
CCNC
Peptide sequence around phosphorylation site of Serine 275(N-G-S(p)-A-N) derived from Human Cyclin C.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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