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Invitrogen™ Phospho-Cyclin C (Ser275) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA537510
Description
A suggested positive control for Western blot is NIH-3T3 or A549 cells; suggested positive control for IHC is human breast carcinoma.
Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk 8, a novel protein kinase of the cdk family. It is suggested that cyclin C and cdk 8 control RNA polymerase II function. Human cdk 8 cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth regulatory signals.
Specifications
Phospho-Cyclin C (Ser275) | |
Polyclonal | |
Unconjugated | |
CCNC | |
AI451004; AU020987; CCNC; CG1C; CycC; cyclin C; cyclin-C; dJ199J3.4 (cyclin C); hSRB11; SRB11 homolog | |
Rabbit | |
Affinity Chromatography | |
RUO | |
114839, 51813, 892 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P24863, P39947, Q62447 | |
CCNC | |
Peptide sequence around phosphorylation site of Serine 275(N-G-S(p)-A-N) derived from Human Cyclin C. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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