Invitrogen™ Phospho-DAPK1 (Ser308) Monoclonal Antibody (DKPS308)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA124738

Catalog No. PIMA124738

Description

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

DAPK1 is a large, calmodulin-dependent kinase involved in gamma-interferon induced programmed cell death and is a potential tumor suppressor. DAPK1 is involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and authophagy. It regulates both type I apoptotic and type II autophagic cell death signal, depending on the cellular setting. Type I apoptotic cell death is caspase-dependent, type II authophagic cell death is caspase-independent. DAPK1 phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. It also phosphorylates TPM1, STX1A, PRKD1, BECN1, TSC2, RPS6, MYL9, and DAPK3.

Specifications

• Antigen: Phospho-DAPK1 (Ser308)
• Classification: Monoclonal
• Concentration: 2.2 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: P53355, Q80YE7
• Gene Symbols: DAPK1
• Immunogen: Synthetic phosphopeptide corresponding to residues 303-312 of human DAP Kinase 1.
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunoprecipitation, Western Blot
• Clone: DKPS308
• Conjugate: Unconjugated
• Gene: DAPK1
• Gene Alias: D13Ucla1; DAP kinase 1; DAPK; DAPK1; DAP-Kinase; death associated protein kinase 1; death-associated protein kinase 1; DKFZp781I035; OTTHUMP00000216193
• Host Species: Mouse
• Purification Method: purified
• Regulatory Status: RUO
• Gene ID (Entrez): 1612, 69635
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov