Invitrogen™ Phospho-DAPK1 (Ser736) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564572

Catalog No. PIPA564572

Description

Phospho-DAPK1 (Ser736) Polyclonal Antibody detects endogenous levels of DAPK1 only when phosphorylated at Ser736.

DAPK1 is a large, calmodulin-dependent kinase involved in gamma-interferon induced programmed cell death and is a potential tumor suppressor. DAPK1 is involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and authophagy. It regulates both type I apoptotic and type II autophagic cell death signal, depending on the cellular setting. Type I apoptotic cell death is caspase-dependent, type II authophagic cell death is caspase-independent. DAPK1 phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. It also phosphorylates TPM1, STX1A, PRKD1, BECN1, TSC2, RPS6, MYL9, and DAPK3.

Specifications

• Antigen: Phospho-DAPK1 (Ser736)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DAPK1
• Gene Alias: D13Ucla1; DAP kinase 1; DAPK; DAPK1; DAP-Kinase; death associated protein kinase 1; death-associated protein kinase 1; DKFZp781I035; OTTHUMP00000216193
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1612, 69635
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 30% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P53355, Q80YE7
• Gene Symbols: DAPK1
• Immunogen: A synthesized peptide derived from human DAPK1 (Phospho-Ser736).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov