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Invitrogen™ Phospho-Dematin (Ser403) Polyclonal Antibody
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Catalog No. PIPA599470
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100 μL
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PIPA599470 100 μL
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Catalog No. PIPA599470 Supplier Invitrogen™ Supplier No. PA599470
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of Dematin only when phosphorylated at Ser403.

The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Dematin (Ser403)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DMTN
Gene Accession No. Q08495, Q9WV69
Gene Alias AI325486; dematin; dematin actin binding protein; dematin actin-binding protein; DMT; Dmtn; Epb4.9; Epb49; Erythrocyte membrane protein band 4.9; erythrocyte membrane protein band 4.9 (dematin); erythrocyte protein band 4.9
Gene Symbols DMTN
Host Species Rabbit
Immunogen A synthesized peptide derived from human DMTN(Accession Q08495), corresponding to amino acid residues around phosphorylated Ser403.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13829, 2039
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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