Invitrogen™ Phospho-DEPDC5 (Ser1530) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106235

Catalog No. PIPA5106235

Description

Antibody detects endogenous levels of DEPDC5 only when phosphorylated at S1530.

This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: Phospho-DEPDC5 (Ser1530)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DEPDC5
• Gene Alias: DEP domain containing 5; DEP domain-containing protein 5; DEP.5; DEPD5; DEPDC5; FFEVF; GATOR complex protein DEPDC5; KIAA0645
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9681
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O75140
• Gene Symbols: DEPDC5
• Immunogen: A synthesized peptide derived from human DEPDC5(Accession O75140), corresponding to amino acid residues around phosphorylated Ser1530.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG