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Invitrogen™ Phospho-Desmin (Ser60) Polyclonal Antibody
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Catalog No. PIPA538837
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100 μg
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Catalog No. Quantity
PIPA538837 100 μg
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Catalog No. PIPA538837 Supplier Invitrogen™ Supplier No. PA538837
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Description

Rabbit Polyclonal Antibody

PA5-38837 has been used successfully in peptide-ELISA at a dilution of 1:10,000.

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Desmin (Ser60)
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco's PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DES
Gene Accession No. P17661, P31001, P48675
Gene Alias CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
Gene Symbols DES
Host Species Rabbit
Immunogen A synthetic phosphopeptide derived from human Desmin around the phosphorylation site of Ser60 (R-T-SP-G-G).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13346, 1674, 64362
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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