Phospho-Desmin (Thr76, Thr77) Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-6476	100 μL

Catalog No. 50-198-6476 Supplier Bioss Supplier No. BS5302R

Description

Rabbit Polyclonal Antibody

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.

Specifications

• Antigen: Phospho-Desmin (Thr76, Thr77)
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: DES
• Gene Accession No.: P17661
• Gene Alias: BOS_2078; CMD1I; CSM1; CSM2; Des; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; mutant desmin p.K241E; SCPNK
• Gene Symbols: DES
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human DES around the phosphorylation site of Thr76/Thr77.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1674
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG