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Phospho-DOK1 (Tyr362) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501986466
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50-198-6466 100 μL
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Catalog No. 50-198-6466 Supplier Bioss Supplier No. BS5289R
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Description

Rabbit Polyclonal Antibody

DOK1 (P62dok, Docking protein 1) is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. DOK1 is a major substrate for many tyrosine kinases including c-kit, v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, DOK1 forms a complex with ras GTPase-activating protein. Phosphorylation on tyrosine residues by the insulin receptor kinase results in the negative regulation of the insulin signaling pathway. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs.

Specifications

Antigen Phospho-DOK1 (Tyr362)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene DOK1
Gene Accession No. Q99704
Gene Alias AW557123; Docking protein 1; docking protein 1, 62kDa (downstream of tyrosine kinase 1); Dok; DOK 1; DOK1; Dok-1; Downstream of tyrosine kinase 1; downstream of tyrosine kinase-1; MGC117395; MGC138860; p240; p62(dok); p62DOK; pp62; TLP1; TP1; TROVE domain family; TROVE1; VAULT2
Gene Symbols DOK1
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr362.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1796
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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