Invitrogen™ Phospho-Doublecortin (Ser297) Polyclonal Antibody

Catalog No.	Quantity
PIPA5104589	100 μL

Catalog No. PIPA5104589

Supplier: Invitrogen™ PA5104589

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of Doublecortin only when phosphorylated at Ser297.

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.

Specifications

• Antigen: Phospho-Doublecortin (Ser297)
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: DCX
• Gene Accession No.: O43602, O88809, Q9ESI7
• Gene Alias: DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
• Gene Symbols: DCX
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human DCX(Accession O43602), corresponding to amino acid residues around phosphorylated Ser297.
• Purification Method: sequential chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 13193, 1641, 84394
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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