Invitrogen™ Phospho-DR6 (Thr460) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105426

Catalog No. PIPA5105426

Description

Antibody detects endogenous levels of DR6 only when phosphorylated at Tyr460.

DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.

Specifications

• Antigen: Phospho-DR6 (Thr460)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNFRSF21
• Gene Alias: AA959878; BM-018; CD358; Death receptor 6; Death receptor-6; DR6; MGC31965; R74815; sCD358; sDR6; soluble CD358; soluble DR6; TNF receptor superfamily member 21; TNFR-related death receptor 6; TNFR-related death receptor-6; Tnfrsf21; TR7; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21; UNQ437/PRO868
• Host Species: Rabbit
• Purification Method: Sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27242, 316256
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: D3ZF92, O75509
• Gene Symbols: TNFRSF21
• Immunogen: A synthesized peptide derived from human TNFRSF21(Accession O75509), corresponding to amino acid residues around phosphorylated Tyr460.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov