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Invitrogen™ Phospho-DR6 (Thr460) Polyclonal Antibody
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Catalog No. PIPA5105426
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PIPA5105426 100 μL
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Catalog No. PIPA5105426 Supplier Invitrogen™ Supplier No. PA5105426
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of DR6 only when phosphorylated at Tyr460.

DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-DR6 (Thr460)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TNFRSF21
Gene Accession No. D3ZF92, O75509
Gene Alias AA959878; BM-018; CD358; Death receptor 6; Death receptor-6; DR6; MGC31965; R74815; sCD358; sDR6; soluble CD358; soluble DR6; TNF receptor superfamily member 21; TNFR-related death receptor 6; TNFR-related death receptor-6; Tnfrsf21; TR7; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21; UNQ437/PRO868
Gene Symbols TNFRSF21
Host Species Rabbit
Immunogen A synthesized peptide derived from human TNFRSF21(Accession O75509), corresponding to amino acid residues around phosphorylated Tyr460.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27242, 316256
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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