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Invitrogen™ Phospho-CRMP1 (Thr509) Polyclonal Antibody
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Catalog No. PIPA5106121
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100 μL
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PIPA5106121 100 μL
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Catalog No. PIPA5106121 Supplier Invitrogen™ Supplier No. PA5106121
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of CRMP-1 only when phosphorylated at Thr509.

Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-CRMP1 (Thr509)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CRMP1
Gene Accession No. P97427, Q14194, Q62950
Gene Alias Collapsin response mediator protein 1; Crmp1; CRMP-1; dihydropyrimidinase-like 1; dihydropyrimidinase-related protein 1; Dpysl1; DRP1; DRP-1; Ulip3; ULIP-3; Unc-33-like phosphoprotein 3
Gene Symbols CRMP1
Host Species Rabbit
Immunogen A synthesized peptide derived from human CRMP1(Accession Q14194), corresponding to amino acid residues around phosphorylated Thr509.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12933, 1400, 25415
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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