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Invitrogen™ Phospho-Dynamin 1 (Ser778) Polyclonal Antibody
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Catalog No. PIPA599143
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PIPA599143 100 μL
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Catalog No. PIPA599143 Supplier Invitrogen™ Supplier No. PA599143
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of DYN1 only when phosphorylated at Sersine 778.

Dynamin is a GTPase required for endocytosis of clathrin coated vesicles from the membrane. Dynamin's involvement in endocytosis was first discovered during the characterization of the temperature sensitive parylytic shibire mutation from Drosophila melanogaster. Three closely related isoforms have been identified in mammals. Dynamin1 is expressed exclusively in neurons, dynamin2 is ubiquitously expressed and dynamin3 is expressed primarily in the testes. Each of these isoforms of dynamin also has several splice variants. This suggests that each isoform/splice variant may have separate intracellular targets or function in the budding of distinct vesicle types. Common domain features of the dynamin proteins include an amino acid terminal GTPase domain, a central pleckstrin homology domain and a highly basic proline rich carboxyl terminus with several Src homology 3 (SH3) domains. These SH3 domains target the dynamin to the clathrin coated pit. Dynamin is known to interact with at least two proteins, AP2 adaptor protein complex and amphiphysin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Dynamin 1 (Ser778)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DNM1
Gene Accession No. P21575, P39053, Q05193
Gene Alias AI838169; B-dynamin; D100; Dnm; Dnm1; Dyn1; dynamin 1; Dynamin BREDNM19; dynamin i; dynamin, brain; Dynamin1; Dynamin-1; EC 3.6.5.5; EIEE31; Ftfl; Kiaa4093; mKIAA4093; Neuronal dynamin; OTTHUMP00000215500
Gene Symbols DNM1
Host Species Rabbit
Immunogen A synthesized peptide derived from human DNM1(Accession Q05193), corresponding to amino acid residues around phosphorylated Ser778.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13429, 140694, 1759
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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