Invitrogen™ Phospho-DYRK1A/DYRK1B (Tyr321, Tyr273) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105874

Catalog No. PIPA5105874

Description

Antibody detects endogenous levels of DYRK1A/B only when phosphorylated at Tyr321/273.

DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2; this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.

Specifications

• Antigen: Phospho-DYRK1A/DYRK1B (Tyr321, Tyr273)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DYRK1A
• Gene Alias: 2310043O08Rik; AOMS3; D16Ertd272e; D16Ertd493e; dual specificity tyrosine phosphorylation regulated kinase 1A; dual specificity tyrosine phosphorylation regulated kinase 1B; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual Specificity Yak1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b; Dyrk; DYRK1; Dyrk1a; Dyrk1b; ENSMUSG00000074897; Gm10783; hMNB; HP86; Minibrain-related kinase; MIRK; Mirk protein kinase; mmb; MNB; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; MP86; MRD7; protein kinase minibrain homolog; PSK47; RP86; serine/threonine kinase MNB; serine/threonine-specific protein kinase
• Host Species: Rabbit
• Purification Method: Sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13548, 13549, 1859, 25255, 308468, 9149
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q13627, Q61214, Q63470, Q9Y463, Q9Z188
• Gene Symbols: DYRK1A, DYRK1B
• Immunogen: A synthesized peptide derived from human DYRK1A(Accession Q13627), corresponding to amino acid residues around phosphorylated Tyr321.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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