Invitrogen™ Phospho-DYRK2/DYRK4 (Tyr382, Tyr264) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564575

Catalog No. PIPA564575

Description

Phospho-DYRK2/DYRK4 (Tyr386, 268) Polyclonal Antibody detects endogenous levels of DYRK2/DYRK4 only when phosphorylated at Tyr386, 268.

DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.

Specifications

• Antigen: Phospho-DYRK2/DYRK4 (Tyr382, Tyr264)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DYRK2
• Gene Alias: 1810038L18Rik; AW049118; dual specificity tyrosine phosphorylation regulated kinase 2; dual specificity tyrosine phosphorylation regulated kinase 4; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4; dual specificity tyrosine-phosphorylation-regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 4; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4; dyrk2; Dyrk4; Dyrk4a; Dyrk4b; RAD51 associated protein 1; Rad51ap1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 101320, 312721, 314862, 69181, 8445, 8798
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q5U4C9, Q8BI55, Q92630, Q9NR20
• Gene Symbols: DYRK2, Dyrk4
• Immunogen: A synthesized peptide derived from human DYRK2/4 (Phospho-Tyr382/264).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov