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Invitrogen™ Phospho-DYRK2/DYRK4 (Tyr382, Tyr264) Polyclonal Antibody
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Catalog No. PIPA564575
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PIPA564575 100 μL
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Catalog No. PIPA564575 Supplier Invitrogen™ Supplier No. PA564575
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Description

Rabbit Polyclonal Antibody

Phospho-DYRK2/DYRK4 (Tyr386, 268) Polyclonal Antibody detects endogenous levels of DYRK2/DYRK4 only when phosphorylated at Tyr386, 268.

DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-DYRK2/DYRK4 (Tyr382, Tyr264)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DYRK2
Gene Accession No. Q5U4C9, Q8BI55, Q92630, Q9NR20
Gene Alias 1810038L18Rik; AW049118; dual specificity tyrosine phosphorylation regulated kinase 2; dual specificity tyrosine phosphorylation regulated kinase 4; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4; dual specificity tyrosine-phosphorylation-regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 4; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4; dyrk2; Dyrk4; Dyrk4a; Dyrk4b; RAD51 associated protein 1; Rad51ap1
Gene Symbols DYRK2, Dyrk4
Host Species Rabbit
Immunogen A synthesized peptide derived from human DYRK2/4 (Phospho-Tyr382/264).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 101320, 312721, 314862, 69181, 8445, 8798
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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