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Invitrogen™ Phospho-EEF2K (Ser78) Polyclonal Antibody
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Catalog No. PIPA5143686
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100 μL
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PIPA5143686 100 μL
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Catalog No. PIPA5143686 Supplier Invitrogen™ Supplier No. PA5143686
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Description

Rabbit Polyclonal Antibody

This antibody detects a 105 kDa* protein corresponding to the molecular mass of eEF2K on SDS-PAGE immunoblots of mouse C2C12 and Jurkat cells treated with Calyculin A, and this reactivity is removed after lambda phosphatase treatment.

EEF2K is a highly conserved Serine/Threoning kinase in the calmodulin signaling pathway whose activity is increased in cancers including breast cancer. EEF2K (eukaryotic elongation factor 2 kinase) is a threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Up activation, by a variety of upstream kinases including AMPK or TRPM7, EEF2K phosphorylates the elongation factor EEF2 at a single site. Then, EEF2K renders EEF2 unable to bind ribosomes and inactive - in turn, the rate of protein synthesis is reduced.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-EEF2K (Ser78)
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene EEF2K
Gene Accession No. O00418, O08796, P70531
Gene Alias C86191; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase; calmodulin-dependent protein kinase III; EC 2.7.11.20; eEF-2 kinase; Eef2k; eEF-2K; EF2K; elongation factor 2 kinase; elongation factor-2 kinase; euk; eukaroytic elongation factor 2 kinase; eukaryotic elongation factor 2 kinase; eukaryotic elongation factor-2 kinase; HSU93850; kinase eEF2K; SMEF2K
Gene Symbols EEF2K
Host Species Rabbit
Immunogen Phospho-eEF2K (Ser-78) synthetic peptide (coupled to carrier protein) corresponds to amino acids surrounding Ser-78 in human eEF2K. This sequence is well conserved in rat and mouse eEF2K, and has low homology to other proteins.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13631, 25435, 29904
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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