Invitrogen™ Phospho-EGFR/ErbB2 (Tyr1173, Tyr1248) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517844

Catalog No. PIPA517844

Description

It is not recommended to aliquot this antibody.

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Specifications

• Antigen: Phospho-EGFR/ErbB2 (Tyr1173, Tyr1248)
• Classification: Polyclonal
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P00533, P04626
• Gene Symbols: EGFR, ERBB2
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pTyr1248 of human ErbB2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: EGFR
• Gene Alias: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; CD340; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; c-erb B2/neu protein; EGFR; Epidermal growth factor receptor; ERBB; ERBB1; ERBB2; erb-b2 receptor tyrosine kinase 1; erb-b2 receptor tyrosine kinase 2; HER1; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; mENA; Metastatic lymph node gene 19 protein; MLN 19; MLN19; NEU; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; NISBD2; Oncogene ERBB; p185erbB2; PIG61; proto-oncogene c-ErbB-1; Proto-oncogene c-ErbB-2; proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-1; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; Urogastrone; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; wa2; Wa5
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1956, 2064
• Content And Storage: -20°C
• Form: Liquid