Invitrogen™ Phospho-EphB4 (Tyr987) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106135

Catalog No. PIPA5106135

Description

Antibody detects endogenous levels of EPHB4 only when phosphorylated at Tyr987.

EPHB4 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

Specifications

• Antigen: Phospho-EphB4 (Tyr987)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EPHB4
• Gene Alias: AI042935; Developmental kinase 2; EPH receptor B4; Ephb4; ephrin receptor EphB4; ephrin type-B receptor 4; Hepatoma transmembrane kinase; HTK; Mdk2; mDK-2; MYK1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; TYRO11; Tyrosine kinase MYK-1; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase TYRO11
• Host Species: Rabbit
• Purification Method: sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2050
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P54760
• Gene Symbols: EPHB4
• Immunogen: A synthesized peptide derived from human EPHB4(Accession P54760), corresponding to amino acid residues around phosphorylated Tyr987.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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