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Phospho-Ephexin-1 (Tyr179) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501982600
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Catalog No. Quantity
50-198-2600 100 μL
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Catalog No. 50-198-2600 Supplier Bioss Supplier No. BS13084R
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Description

Rabbit Polyclonal Antibody

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.

Specifications

Antigen Phospho-Ephexin-1 (Tyr179)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene NGEF
Gene Accession No. Q8N5V2
Gene Alias ARHGEF27; Besh3; brain-enriched SH3-domain protein Besh3; ephexin; Ephexin-1; Eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor; NGEF; Tims2; transforming immortalised mammary epithelial sequence 2
Gene Symbols NGEF
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human Ephexin-1 around the phosphorylation site of Tyr179.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25791
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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