Invitrogen™ Phospho-EpoR (Tyr426) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106138

Catalog No. PIPA5106138

Description

Antibody detects endogenous levels of Epo-R only when phosphorylated at Tyr426.

EpoR encodes the erythropoietin receptor, which belongs to the cytokine receptor family. When erythropoietin binds to this receptor, it activates the Jak2 tyrosine kinase, which in turn activates various intracellular pathways including Ras/MAP kinase, phosphatidylinositol 3-kinase, and STAT transcription factors. The stimulated erythropoietin receptor plays a role in the survival of erythroid cells. Defects in this gene may result in erythroleukemia and familial erythrocytosis. Dysregulation of this gene may also affect the growth of certain tumors. Multiple transcript variants are produced as a result of alternate splicing. Diseases associated with EPOR include Erythrocytosis, Familial, 1 and Erythroleukemia.

Specifications

• Antigen: Phospho-EpoR (Tyr426)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EPOR
• Gene Alias: EPO R; EPOR; EPO-R; Erythropoietin receptor; pEpoR
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13857, 2057, 24336
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P14753, P19235, Q07303
• Gene Symbols: EPOR
• Immunogen: A synthesized peptide derived from human EPOR(Accession P19235), corresponding to amino acid residues around phosphorylated Tyr426.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG