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Invitrogen™ Phospho-FADD (Ser194) Polyclonal Antibody
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Catalog No. PIPA5110120
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100 μL
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PIPA5110120 100 μL
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Catalog No. PIPA5110120 Supplier Invitrogen™ Supplier No. PA5110120
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AMSPM.

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-FADD (Ser194)
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 3.22 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene FADD
Gene Accession No. Q13158
Gene Alias Fadd; Fas (TNFRSF6)-associated via death domain; Fas associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Mort1/FADD; protein FADD
Gene Symbols FADD
Host Species Rabbit
Immunogen A synthetic phosphorylated peptide around S194 of human FADD (NP_0038151).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8772
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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