Phospho-FADD (Ser194) Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-6731	100 μL

Catalog No. 50-198-6731 Supplier Bioss Supplier No. BS5699R

Description

Rabbit Polyclonal Antibody

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Specifications

• Antigen: Phospho-FADD (Ser194)
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: FADD
• Gene Accession No.: Q13158
• Gene Alias: Fadd; Fas (TNFRSF6)-associated via death domain; Fas associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Mort1/FADD; Protein FADD
• Gene Symbols: FADD
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human FADD around the phosphorylation site of Ser194.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8772
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG