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Phospho-FLT3 (Tyr969) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985180
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50-198-5180 100 μL
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Catalog No. 50-198-5180 Supplier Bioss Supplier No. BS3151R
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Description

Rabbit Polyclonal Antibody

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Specifications

Antigen Phospho-FLT3 (Tyr969)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene FLT3
Gene Accession No. P36888
Gene Alias B230315G04; CD135; CD135 antigen; Fetal liver kinase 2; Fetal liver kinase-2; FL cytokine receptor; FLK2; Flk-2; Flt3; Flt-3; fms related tyrosine kinase 3; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; Ly72; OTTHUMP00000214829; Receptor-type tyrosine-protein kinase FLT3; RP11-153M24.3; Stem cell tyrosine kinase 1; STK1; STK-1; tyrosine-protein kinase FLT3; Tyrosine-protein kinase receptor flk-2; wmfl
Gene Symbols FLT3
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human FLT3 around the phosphorylation site of Tyr969.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2322
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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