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Invitrogen™ Phospho-FOXL2 (Ser238) Polyclonal Antibody
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Catalog No. PIPA5105190
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PIPA5105190 100 μL
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Catalog No. PIPA5105190 Supplier Invitrogen™ Supplier No. PA5105190
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of FOXL2 only when phosphorylated at Ser238.

FOXL2 is a winged helix/forkhead transcription factor that is highly conserved in human, goat, mouse, and certain aquatic species. Given its cross-species conservation, it appears to play a critical role evolutionarily, likely in ovarian differentiation in mammals and in ovarian somatic cell differentiation and in further follicle development and/or maintenance. Immunohistochemical data shows that FOXL2 is a nuclear protein specifically expressed in eyelids and in fetal and adult ovarian follicular cells. It does not undergo any major posttranslational modifications. FOXL2 is also found to be associated with blepharo-phimosis/ptosis/epicanthus inverses syndrome (BPES). There are two forms of BPES. Type I BPES shows eyelid abnormal-ities that are associated with ovarian failure. In type II BPES, only eyelid defects are found. Studies have shown that FOXL2 is expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-FOXL2 (Ser238)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene FOXL2
Gene Accession No. O88470, P58012
Gene Alias AU045128; Blepharophimosis; BPES; BPES1; epicanthus inversus; forkhead box L2; forkhead box protein L2; forkhead transcription factor; forkhead transcription factor FOXL2; forkhead transcription factor L2; Foxl2; LUSTR2; MGC14393; Pfrk; P-Frk; PINTO; pituitary forkhead factor; POF3; putative transcription factor foxl2
Gene Symbols FOXL2
Host Species Rabbit
Immunogen A synthesized peptide derived from human FOXL2(Accession P58012), corresponding to amino acid residues around phosphorylated Ser238.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26927, 668
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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