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Invitrogen™ Phospho-GAB1 (Tyr627) Monoclonal Antibody (T.921.2)
Rabbit Monoclonal Antibody
Supplier: Invitrogen™ MA514812
Description
MA5-14812 detects Phospho-GAB1 pTyr627 in human samples. Predicted to react with mouse and rat based on sequence homology. MA5-14812 has been successfully used in Western blot applications. The MA5-14812 immunogen is synthetic phosphopeptide corresponding to residues surrounding Tyr627 of human Gab1. MA5-14812 detects Phospho-Gab1 (Tyr627) which has a predicted molecular weight of approximately 110 kDa.
Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation and apoptosis. Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet-derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c-Met), and epidermal growth factor receptor (EGF), as well as in response to cell-cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3-kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.
Specifications
Phospho-GAB1 (Tyr627) | |
Monoclonal | |
20 μg/mL | |
0.01M HEPES with 0.1mg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5 | |
Q13480 | |
GAB1 | |
Synthetic phosphopeptide corresponding to residues surrounding Tyr627 of human Gab1. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Western Blot | |
T.921.2 | |
Unconjugated | |
GAB1 | |
AA408973; AW107238; EGK_16125; GAB1; GRB2 associated binding protein 1; GRB2-associated binder 1; GRB2-associated binding protein 1; GRB2-associated binding protein 1 long isoform; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1; OTTHUMP00000220263 | |
Rabbit | |
Purified | |
RUO | |
2549 | |
-20°C | |
Liquid |
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