Invitrogen™ Phospho-GAB2 (Tyr643) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114680

Catalog No. PIPA5114680

Description

Antibody detects endogenous levels of Gab2 only when phosphorylated at tyrosine 643.

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

Specifications

• Antigen: Phospho-GAB2 (Tyr643)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GAB2
• Gene Alias: AI463667; D130058I17Rik; GAB2; Grb2 associated binder 2; GRB2 associated binding protein 2; GRB2-associated binder 2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; GRB3-3; Growth factor receptor bound protein 2-associated protein 2; KIAA0571; p97; PH domain-containing adaptor molecule p97; pp100
• Host Species: Rabbit
• Purification Method: Sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14389, 84477, 9846
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9EQH1, Q9UQC2, Q9Z1S8
• Gene Symbols: GAB2
• Immunogen: A synthesized peptide derived from human GAB2(Accession Q9UQC2), corresponding to amino acid residues around phosphorylated Tyr643.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG