Phospho-GSK3 alpha (Ser21)Rabbit anti-Human, Polyclonal, Rockland™

Catalog No.	Quantity
50-199-1742	100 μg

Catalog No. 50-199-1742 Supplier Rockland Immunochemicals Supplier No. 600401429

Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity-purified antibody is directed against the phosphorylated form of human GSK3A at the pS 21 residue. This phospho specific polyclonal antibody reacts with phosphorylated pS21 of human GSK3A. Reactivity with non-phosphorylated human GSK3A is minimal. A BLAST analysis was used to suggest reactivity with this protein from human, chimpanzee and rat based on 100% homology for the immunogen sequence. Cross reactivity with GSK3A homologues from other sources has not been determined.

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.

Specifications

• Antigen: Phospho-GSK3 alpha (Ser21)
• Applications: ELISA, Immunofluorescence, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1.28 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene: Gsk3a
• Gene Accession No.: P49840
• Gene Alias: 2700086H06Rik; DKFZp686D0638; FA; Factor A; glycogen synthase kinase 3 alpha; glycogen synthase kinase 3 alpha b; Glycogen synthase kinase-3 alpha; GSK3; GSK-3 alpha; GSK-3[a]; GSK-3[b]; Gsk3a; gsk3ab; OTTHUMP00000198368; Serine/threonine-protein kinase GSK3A
• Gene Symbols: Gsk3a
• Host Species: Rabbit
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2931
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid