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Invitrogen™ Phospho-HCN1 (Ser846) Polyclonal Antibody
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Catalog No. PIPA5105316
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Quantity:
100 μL
Catalog No. Quantity
PIPA5105316 100 μL
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Catalog No. PIPA5105316

Supplier: Invitrogen™ PA5105316

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of HCN1 only when phosphorylated at Ser846.

HCN1 includes Hyperpolarization-activated cation channels of the HCN gene family, which contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-HCN1 (Ser846)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene HCN1
Gene Accession No. O60741, O88704, Q9JKB0
Gene Alias Bcng1; BCNG-1; Brain cyclic nucleotide-gated channel 1; C630013B14Rik; EIEE24; Hac2; HAC-2; Hcn1; hyperpolarization activated cyclic nucleotide gated potassium channel 1; hyperpolarization-activated cation channel 2; hyperpolarization-activated cyclic nucleotide-gated potassium channel 1; hyperpolarization-activated, cyclic nucleotide-gated K+ 1; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Gene Symbols HCN1
Host Species Rabbit
Immunogen A synthesized peptide derived from human HCN1(Accession O60741), corresponding to amino acid residues around phosphorylated Ser846.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15165, 348980, 84390
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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