Invitrogen™ Phospho-HDAC5/HDAC9 (Ser259, Ser220) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA540215

Catalog No. PA540215

Description

This antibody is predicted to react with mouse based on sequence homology.

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Specifications

• Antigen: Phospho-HDAC5/HDAC9 (Ser259, Ser220)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HDAC9
• Gene Alias: Antigen NY-CO-9; HD5; HD7; HD7b; HD9; HDAC; HDAC5; HDAC7; HDAC7B; HDAC9; hdac-9; HDAC9B; HDAC9FL; HDRP; histone deacetylase 4/5-related protein; histone deacetylase 5; Histone deacetylase 7B; histone deacetylase 9; Histone deacetylase-related protein; KIAA0600; KIAA0744; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR; MITR; NY-CO-9
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10014, 15184, 79221, 9734
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q99N13, Q9UKV0, Q9UQL6, Q9Z2V6
• Gene Symbols: HDAC5, HDAC9
• Immunogen: Synthesized peptide derived from human HDAC5/9 around the phosphorylation site of S259/220.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov