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Phospho-HDAC8 (Ser39) Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS3127R

Catalog No. 50-198-5161


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Description

Description

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.
Specifications

Specifications

Phospho-HDAC8 (Ser39)
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
HDAC8
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
55869
HDAC8
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Q9BY41
2610007D20Rik; CDA07; CDLS5; HD8; HDAC8; HDACL1; Histone deacetylase 8; histone deacetylase-like 1; MRXS6; RGD1562895; RPD3; WTS
KLH conjugated synthetic phosphopeptide derived from human HDAC8 around the phosphorylation site of Ser39.
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
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