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Invitrogen™ Phospho-HGS (Tyr216) Polyclonal Antibody
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Catalog No. PIPA5114579
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100 μL
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PIPA5114579 100 μL
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Catalog No. PIPA5114579 Supplier Invitrogen™ Supplier No. PA5114579
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of HGS only when phosphorylated at Tyr216.

HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-HGS (Tyr216)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene HGS
Gene Accession No. O14964, Q99LI8, Q9JJ50
Gene Alias hepatocyte growth factor-regulated tyrosine kinase substrate; HGF-regulated tyrosine kinase substrate; HGNC:4897; Hgr; Hgs; Hrs; Hrs2; human growth factor-regulated tyrosine kinase substrate; protein pp110; SNAP-25-interacting protein Hrs-2; ZFYVE8
Gene Symbols HGS
Host Species Rabbit
Immunogen A synthesized peptide derived from human HGS around the phosphorylation site of Tyr216.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15239, 56084, 9146
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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