Invitrogen™ HIPK2 Polyclonal Antibody

Catalog No.	Quantity
PIPA5102964	100 μL

Catalog No. PIPA5102964 Supplier Invitrogen™ Supplier No. PA5102964

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total HIPK2.

The HIPK2 gene encodes a member of the homeodomain-interacting protein kinase family, specifically a serine/threonine nuclear protein kinase. HIPK2 plays versatile roles in cellular processes, including transcription regulation, cell proliferation, differentiation, and apoptosis. It interacts with various transcription factors and proteins, contributing significantly to the modulation of gene expression. Notably, HIPK2 is involved in the activation of the tumor suppressor protein p53, with p53-dependent pro-apoptotic activity, positioning HIPK2 as a potential tumor suppressor gene. Recent studies highlight its downregulation in multiple tumor types and its emerging role in cancer biology and therapy. Its expression is subject to quality control mechanisms, including autophosphorylation at serine and threonine sites. Structurally, the crystal structure of HIPK2 reveals unique conformational attributes that contribute to its functionality in different signaling pathways. HIPK2's influence extends to physiological processes, such as fibrosis and central nervous system regulation, indicating its broad biological significance and potential therapeutic applications.

Specifications

• Antigen: HIPK2
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: HIPK2
• Gene Accession No.: Q9H2X6, Q9QZR5
• Gene Alias: 1110014O20Rik; B230339E18Rik; cb1009; hHIPk2; HIPK2; homeodomain interacting protein kinase 2; homeodomain-interacting protein kinase 2; Nbak1; Nuclear body-associated kinase 1; PRO0593; si:dkey-16j24.2; si:dkey-239k7.1; Sialophorin tail-associated nuclear serine/threonine-protein kinase; Stank; wu:fk56d12
• Gene Symbols: HIPK2
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human HIPK2(Accession Q9H2X6), corresponding to amino acid residues F15-T65.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 15258, 28996
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov