Invitrogen™ Phospho-Histone H2A/H4 (Ser1) Recombinant Rabbit Monoclonal Antibody (RM216)

Catalog No.	Quantity
PIMA524692	100 μg

Catalog No. PIMA524692 Supplier Invitrogen™ Supplier No. MA524692

Description

Rabbit Recombinant Monoclonal Antibody

This antibody reacts to Histone H4 or Histone H2A phosphorylated at Serine 1. No cross reactivity with other phosphorylated Histones. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Specifications

• Antigen: Phospho-Histone H2A/H4 (Ser1)
• Applications: ELISA, Western Blot, Luminex, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: RM216
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 1% BSA and 0.09% sodium azide; pH 7.2-7.4
• Gene: H2AC11
• Gene Accession No.: P04908, P0C0S8, P20671, P62805, Q96KK5, Q99878
• Gene Alias: dJ160A22.4; dJ86C11.1; H2A histone family member; H2A histone family, member E; H2A histone family, member G; H2A histone family, member M; H2A histone family, member P; H2A.1; H2A.1b; H2A.3; H2A/E; H2A/g; H2A/m; H2A/p; H2A/S; H2AC11; H2AC13; H2AC15; H2AC16; H2AC17; H2AFA; H2AFALii; H2AFC; H2AFD; H2AFE; H2AFG; H2AFI; H2AFM; H2AFN; H2AFP; H2AG; H2AH; H4 histone family, member A; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4-16; H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4F2; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; HIST1H2AB; HIST1H2AD; HIST1H2AE; HIST1H2AG; HIST1H2AH; HIST1H2AI; HIST1H2AJ; HIST1H2AK; HIST1H2AL; HIST1H2AM; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4; HIST2H4A; HIST2H4B; HIST4H4; histone 1, H2ab; histone 1, H2ad; histone 1, H2ag; histone 1, H2aj; histone 1, H4a; histone cluster 1, H2ab; histone cluster 1, H2ad; histone cluster 1, H2ag; histone cluster 1, H2ah; histone cluster 1, H2aj; histone cluster 1, H4a; histone H2A type 1; Histone H2A type 1-B/E; histone H2A type 1-D; Histone H2A type 1-H; Histone H2A type 1-J; Histone H2A.2; Histone H2A.3; Histone H2A/a; Histone H2A/e; Histone H2A/g; histone H2A/m; histone H2A/p; Histone H2A/ptl; Histone H2A/s; histone H2AD; histone H4; pH2A/f
• Gene Symbols: H2AC11, H2AC12, H2AC14, H2AC4, H2AC7, H4C1
• Host Species: Rabbit
• Immunogen: Phospho-peptide corresponding to Phospho-Histone H2A (pSer1).
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3013, 8331, 8335, 8359, 85235, 8969
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG