Invitrogen™ Phospho-hnRNP D (Ser83) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599478

Catalog No. PIPA599478

Description

Antibody detects endogenous levels of hnRPD only when phosphorylated at Ser83.

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.

Specifications

• Antigen: Phospho-hnRNP D (Ser83)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HNRNPD
• Gene Alias: ARE-binding protein AUFI, type A; Auf1; AUF1A; AU-rich element RNA binding protein 1, 37kDa; AU-rich element RNA-binding factor 1; AU-rich element RNA-binding protein 1; heterogeneous nuclear ribonucleoprotein D; heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa); heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; HNRNPD; hnRNPD0; Hnrpd; P37; RNA binding protein p45AUF1
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11991, 3184
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q14103, Q60668
• Gene Symbols: HNRNPD
• Immunogen: A synthesized peptide derived from human HNRNPD(Accession Q14103), corresponding to amino acid residues around phosphorylated Ser83.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov