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Phospho-HP1 (Tyr43) Rabbit anti-Drosophila, Polyclonal, Bioss
SDP

Catalog No. 501980586
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50-198-0586 100 μL
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Catalog No. 50-198-0586 Supplier Bioss Supplier No. BS0930R
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Description

Rabbit Polyclonal Antibody

HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. HP1 proteins are relatively small proteins (˜25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin.

Specifications

Antigen Phospho-HP1 (Tyr43)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from Drosophila Melanogaster HP1 around the phosphorylation site of Tyr43.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Drosophila
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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