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Invitrogen™ Phospho-HPD (Thr382) Polyclonal Antibody
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Catalog No. PIPA5106228
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PIPA5106228 100 μL
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Catalog No. PIPA5106228 Supplier Invitrogen™ Supplier No. PA5106228
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of HPD only when phosphorylated at Thr382.

The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-HPD (Thr382)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Hpd
Gene Accession No. P32754, P32755, P49429
Gene Alias 4H GLOD3; 4-H HPPDASE; 4HPPD; 4-HPPD; 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; f Alloantigen; F liver antigen; f protein; Fla; Flp; GLOD3; glyoxalase domain containing 3; HPD; Hppd; HPPDASE; Laf; PPD
Gene Symbols Hpd
Host Species Rabbit
Immunogen A synthesized peptide derived from human HPD(Accession P32754), corresponding to amino acid residues around phosphorylated Thr382.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15445, 29531, 3242
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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